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Related Experiment Videos

Antibiotic use in the elderly: issues and nonissues.

J D McCue1

  • 1University of Massachusetts Medical School and the Department of Medicine, Berkshire Medical Center, Pittsfield 01201, USA. drjmccue@massmed.org

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|May 29, 2000
PubMed
Summary

Antibiotic therapy for elderly patients generally mirrors that for younger individuals, with dose adjustments for reduced kidney function. Empirical antibiotic therapy for serious infections in older adults requires a broader spectrum due to increased bacterial diversity and polymicrobial infections.

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Antibiotic resistance: why is it increasing in nursing homes?

Geriatrics·1997

Area of Science:

  • Geriatrics
  • Infectious Diseases
  • Pharmacology

Background:

  • Elderly populations face increased mortality and morbidity from infections.
  • Standard antibiotic use in older adults requires careful consideration of physiological changes.

Purpose of the Study:

  • To outline appropriate antibiotic use in elderly patients.
  • To highlight key differences in antibiotic selection and dosing for geriatric patients.

Main Methods:

  • Review of current literature on antibiotic pharmacokinetics and pharmacodynamics in the elderly.
  • Analysis of infection patterns and treatment considerations in older adults.

Main Results:

  • Antibiotic absorption is similar in elderly and younger patients; oral antibiotics can be used for similar indications.

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  • Reduced lean body weight and renal function necessitate dose reduction and longer intervals for renally excreted antibiotics.
  • Conservative therapy length is advised due to complicating predispositions to infection.

    • Conclusions:

    • Antibiotic therapy in the elderly is largely similar to younger patients, with crucial dose and interval adjustments.
    • Broader-spectrum empirical therapy is essential for serious infections in older adults, particularly long-term residents, due to diverse and polymicrobial infections.