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A biodegradable multiblock co-polymer derived from an alpha, omega-bis(methylamino)peptide and an alpha,
S E Matthews11, C W Pouton, M D Threadgill
1Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, BA2 7AY, Bath, UK.
Abstract:
A novel peptide containing the lysosomally degradable sequence GlyPheLeuGly and a sequence-inverting unit has been prepared. This peptide presents the methylamino groups of sarcosine (N-methylglycine) at both termini for co-polymerisation with alpha, omega-bis(oxiranylmethoxy)poly(ethylene glycol) of mean M(w) 1650. Gel permeation chromatographic analysis showed the presence of a mixture of oligomers. Preliminary degradation studies showed that these oligomers are cleaved by cathepsin B, an important lysosomal enzyme.