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Related Experiment Videos

Duration and frequency mismatch negativity in schizophrenia.

P T Michie1, T W Budd, J Todd

  • 1Department of Psychiatry and Behavioural Science, University of Western Australia, Perth, Australia. pat@psy.uwa.edu.au

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|May 29, 2000
PubMed
Summary

Mismatch negativity (MMN) event-related potentials (ERPs) are reduced in schizophrenia, particularly for duration changes. This suggests temporal processing deficits in schizophrenia, impacting auditory cortex and pre-frontal networks.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Auditory Perception

Background:

  • The mismatch negativity (MMN) waveform of event-related potentials (ERPs) is often reported as reduced in schizophrenia.
  • However, some studies show no reduction in frequency MMN, creating inconsistencies in the literature.

Purpose of the Study:

  • To investigate the reasons for conflicting findings regarding MMN in schizophrenia.
  • To determine factors influencing MMN reductions in schizophrenia patients.

Main Methods:

  • Recorded event-related potentials (ERPs) in 14 schizophrenia patients and 17 controls.
  • Presented auditory stimuli with varying frequencies and durations, analyzing mismatch negativity (MMN) to different deviants.

Main Results:

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  • MMN was significantly reduced in schizophrenia patients only for duration deviants.
  • A trend towards reduced MMN was observed for large frequency deviants.

Conclusions:

  • Deviant probability, degree of deviance, and interstimulus interval influence frequency MMN in schizophrenia.
  • Schizophrenia patients may have specific deficits in auditory temporal processing, implicating brain networks.