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Some allylic substituent effects in ring-closing metathesis reactions: allylic alcohol activation
1Department of Chemistry, University of Minnesota, Minneapolis 55455, USA. hoye@chem.umn.edu
Organic Letters
|May 29, 2000
Abstract:
[formula: see text] Dienes 2a-e were used to study allylic substituent effects in the ring-closing metathesis reaction (RCM). Both the steric and electronic character of the allylic substituents were found to influence alkene reactivities. Free allylic hydroxyl groups exert a large activating effect on the RCM reaction rates.