Oromandibular-limb hypogenesis spectrum and maternal lithium use

Area of Science:

• Medical genetics
• Developmental biology
• Teratology

Background:

• Oromandibular-limb hypogenesis spectrum disorders are rare congenital anomalies.
• Maternal lithium exposure during pregnancy is a known risk factor for certain birth defects.

Observation:

• A female infant presented with features consistent with oromandibular-limb hypogenesis spectrum.
• The infant's mother reported taking lithium medication throughout her pregnancy.

Findings:

• This case highlights a potential association between prenatal lithium exposure and oromandibular-limb hypogenesis spectrum.
• Further research is warranted to elucidate the teratogenic mechanisms of lithium in this context.

Implications:

• Clinicians should consider maternal medication history, including lithium, when evaluating infants with oromandibular-limb hypogenesis spectrum.
• This case contributes to understanding the spectrum of congenital anomalies associated with prenatal lithium exposure.