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Botulinum toxin type A therapy for palmar and digital hyperhidrosis.
1State University of New York, Health Science Center at Brooklyn, USA.
Journal of the American Academy of Dermatology
|May 29, 2000
Summary
Subepidermal injections of botulinum toxin type A effectively treated recalcitrant palmar and digital hyperhidrosis. This method offered a safe and long-lasting alternative for excessive sweating in the hands and digits.
Area of Science:
- Dermatology
- Neurology
- Medical Aesthetics
Background:
- Palmar and digital hyperhidrosis significantly impact quality of life.
- Recalcitrant cases often require advanced treatment modalities.
Purpose of the Study:
- To assess the efficacy of subepidermal botulinum toxin type A injections for severe palmar and digital hyperhidrosis.
Main Methods:
- Twenty patients with recalcitrant hyperhidrosis received subepidermal botulinum toxin injections.
- Treatment involved 3 stages with a total dose of 165 units per hand.
- Nineteen patients completed the 12-month follow-up period.
Main Results:
- Botulinum toxin significantly reduced sweat production in treated palms and digits.
- Anhidrosis duration varied, with most patients experiencing relief for 4-9 months.
- Reduced sweating persisted for 12 months; mild thumb weakness was transient in 4 patients.
Conclusions:
- Subepidermal botulinum toxin type A is a safe and effective treatment for recalcitrant palmar and digital hyperhidrosis.
- The treatment offers a viable alternative for patients unresponsive to conventional therapies.