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Related Experiment Videos

[Pseudo-Meigs' syndrome].

B Wiatrowska1, P Krajci, A Berner

  • 1Avdeling for patologi, Det Norske Radiumhospital, Oslo.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|May 29, 2000
PubMed
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Distinguishing ovarian tumor spread in effusions is crucial. Immunocytochemistry aids diagnosis when cytology is unclear, as seen in a pseudo-Meigs

Area of Science:

  • Cytopathology and Surgical Pathology
  • Gynecologic Oncology
  • Immunohistochemistry

Background:

  • Cytologic examination of body cavity effusions differentiates reactive processes from ovarian tumor spread.
  • Malignant cells in effusions indicate metastatic disease and poor prognosis, while benign effusions do not impact staging or prognosis.
  • Distinguishing reactive mesothelial cells from cancer cells can be challenging based on morphology alone.

Observation:

  • A 42-year-old woman presented with a pelvic mass, ascites, and hydrothorax.
  • Preoperative pleural fluid cytology was inconclusive.
  • Immunocytochemistry (BerEP4, B72.3, CA 125, CD15, CEA, E-cadherin, calretinin) on cell block sections revealed reactive mesothelial cells, with no epithelial cells detected.

Findings:

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  • Adnexal tumor removal revealed a borderline mucinous tumor of the ovary.
  • Post-surgery, ascites and hydrothorax resolved.
  • The case highlights the diagnostic utility of immunocytochemistry in equivocal effusion cytology.

    • Implications:

    • Immunocytochemistry is a valuable ancillary tool for diagnosing body cavity effusions in patients with suspected ovarian tumors.
    • Accurate diagnosis of effusion cytology is critical for patient management and prognosis.
    • Understanding pseudo-Meigs' syndrome is important in the differential diagnosis of ascites and hydrothorax in women with pelvic masses.