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[Meniere's disease. The clinical effect of gentamicin treatment]
1Arhus Universitetshospital, Arhus Kommunehospital, øre-naese-hals-afdelingen.
Abstract:
In patients with Menière's disease attacks of vertigo can be invalidating. We have tested the effect of instillation of gentamycin in the middle ear to minimize or stop the attacks of vertigo. The results of a prospective investigation of 14 patients with Menière's disease treated with gentamycin in the period from 1993 to 1996 are presented. The patients were followed up to 53 months after the treatment and a telephone follow-up was performed. At the last follow-up nine out of 12 patients were free of attacks of vertigo. Two improved and one patient was unchanged. In two patients deafness developed in the treated ear, in the other patients the hearing was unchanged measured by speech reception threshold and discrimination loss. It is concluded that treatment of patients with Menière's disease by instillation of gentamycin into the middle ear does have a therapeutic effect. The treatment is simple and the effect of treatment is equal to other types of treatments. The risk of deafness in the treated ears stresses the importance of giving the patient sufficient information before treatment.
Insights
Instilling gentamicin into the middle ear effectively reduced vertigo attacks in Meniere
Area of Science:
- Otolaryngology
- Neurology
- Pharmacology
Context:
- Meniere's disease causes debilitating vertigo attacks.
- Current treatments for Meniere's disease have limitations.
- Intratympanic gentamicin offers a potential therapeutic option.
Purpose:
- To evaluate the efficacy of middle ear gentamicin instillation for Meniere's disease vertigo.
- To assess the impact of this treatment on vertigo, hearing, and quality of life.
Summary:
- A prospective study involved 14 Meniere's disease patients treated with middle ear gentamicin.
- Follow-up up to 53 months showed 9 of 12 patients became vertigo-free.
- Two patients developed deafness; hearing remained stable in others.
Impact:
- Middle ear gentamicin instillation demonstrates significant therapeutic effect for Meniere's disease vertigo.
- This treatment is simple and comparable to other therapies.
- Informed consent is crucial due to the risk of treatment-induced deafness.