Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current issues on epileptic women.

J Pimentel1

  • 1Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal. cortezpimentel@ip.pt

Current Pharmaceutical Design
|June 1, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Septic arthritis of the temporomandibular joint managed with arthroscopy: a case report.

International journal of oral and maxillofacial surgery·2023
Same author

Diagnostic yield of muscle biopsies in pediatric population: a tertiary center experience.

Revista de neurologia·2021
Same author

Review: Challenges in the histopathological classification of ganglioglioma and DNT: microscopic agreement studies and a preliminary genotype-phenotype analysis.

Neuropathology and applied neurobiology·2018
Same author

EUFOREA Rhinology Research Forum 2016: report of the brainstorming sessions on needs and priorities in rhinitis and rhinosinusitis.

Rhinology·2017
Same author

Eslicarbazepine acetate as adjunctive therapy in clinical practice: ESLADOBA study.

Acta neurologica Scandinavica·2017
Same author

Dumbbell-shaped spinal solitary fibrous tumor: Combined approach and a review of the literature.

Neuro-Chirurgie·2015
Same journal

Overcoming Physiological Barriers in Brain Tumor Therapy: Advances in Nanomedicine, Ultramolecular Pharmaceuticals, and Targeted Drug Delivery.

Current pharmaceutical design·2026
Same journal

Breathing Life into Research: The Transformative Potential of Lung-on-a-Chip Technology.

Current pharmaceutical design·2026
Same journal

Cross-Tissue Transcriptome-Wide Association Study Prioritizes Candidate Genes and Compound-Associated Signatures for Osteoarthritis.

Current pharmaceutical design·2026
Same journal

Emerging Role of AI in Gastroenterology and Hepatology: Revolutionizing Medical Device-Assisted Diagnosis.

Current pharmaceutical design·2026
Same journal

Nanostructured Lipid Carriers in Drug Targeting: Characterization, Patents, and Recent Innovations.

Current pharmaceutical design·2026
Same journal

Corrigendum to: miRNA in Diagnosis and Therapeutics of Tuberculosis: Importance in Latent and Brain Associated Pathologies.

Current pharmaceutical design·2026
See all related articles

Epileptic women experience hormonal influences on brain activity, affecting seizure patterns. Management involves careful consideration of reproductive health, contraception, pregnancy, and breastfeeding.

Area of Science:

  • Neuroendocrinology
  • Reproductive Medicine
  • Epileptology

Background:

  • Ovarian steroid hormones, particularly estradiol, impact brain function, increasing seizure susceptibility.
  • Hormonal fluctuations during menses and menopause are linked to catamenial epilepsy and altered seizure phenotypes.
  • Epilepsy and its treatments can disrupt the reproductive system, causing endocrinal abnormalities, infertility, and sexual dysfunction.

Purpose of the Study:

  • To review the complex interplay between epilepsy and female reproductive health.
  • To provide guidance on managing epilepsy in women, considering hormonal changes and reproductive concerns.
  • To inform clinical practice regarding contraception, pregnancy, and breastfeeding in epileptic women.

Main Methods:

  • Literature review of studies on epilepsy, ovarian hormones, and reproductive health.

Related Experiment Videos

  • Analysis of the effects of estradiol on hippocampal excitability.
  • Examination of epilepsy's impact on endocrine function, fertility, and sexual health.
  • Review of management strategies for contraception, pregnancy, and breastfeeding in epileptic women.

    • Main Results:

    • Estradiol can increase hippocampal excitability, predisposing to seizures.
    • Hormonal changes during the menstrual cycle and menopause are associated with specific seizure patterns.
    • Epilepsy and antiepileptic drugs (AEDs) can lead to infertility (e.g., polycystic ovaries with valproate) and sexual dysfunction.
    • Oral contraceptives require higher estrogen content (>50mg) to counteract enzyme-inducing AEDs.
    • Pregnancy in epileptic women carries risks of increased seizure frequency, teratogenesis, and obstetric complications, necessitating folic acid and vitamin K supplementation.
    • Breastfeeding is generally safe for epileptic women on AEDs.

    Conclusions:

    • Epilepsy management in women requires a comprehensive approach addressing hormonal influences and reproductive health.
    • Contraception, pregnancy planning, and breastfeeding decisions must be individualized, considering potential risks and benefits.
    • Further research is needed to optimize reproductive health outcomes for women with epilepsy.