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Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1
1Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, Brescia University Medical School, Italy.
Cytogenetics and Cell Genetics
|June 1, 2000
Abstract:
In the present study, we report the genomic reconstruction of the glutamate receptor GluR5 gene (GRIK1, alias GLUR5; 402 kb) by the use of the data available in public databases. This analysis allowed characterization of the exon-intron boundaries, identification of the gene promoter region, presentation of the putative complete sequences of two GluR5 mRNA isoforms, and definition of the structure of GluR5 pre-mRNA surrounding the Q/R editing site.