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Minocycline-induced lupus. A systematic review
R G Schlienger1, A J Bircher, C R Meier
1Division of Clinical Pharmacology, University Hospital, Basel, Switzerland. rschlienger@uhbs.ch
Dermatology (Basel, Switzerland)
|June 1, 2000
Summary
Minocycline use can lead to drug-induced lupus, an autoimmune condition. Monitoring liver function and ANA tests is recommended for patients on long-term minocycline therapy.
Area of Science:
- Autoimmune diseases
- Pharmacovigilance
- Dermatology
Background:
- Minocycline is linked to adverse autoimmune reactions.
- Drug-induced lupus is a known complication.
Purpose of the Study:
- To define the scope of minocycline-induced lupus.
- To characterize its typical clinical features.
Main Methods:
- Comprehensive literature search of case reports.
- Inclusion of English and non-English literature.
Main Results:
- 57 cases of minocycline-induced lupus were identified.
- Common features include polyarthralgia/polyarthritis and liver abnormalities.
- All patients tested positive for antinuclear antibodies (ANA).
Conclusions:
- Long-term minocycline exposure may trigger drug-induced lupus.
- Routine monitoring of liver function and ANA is advised.
- Clinical surveillance is crucial for patients on long-term minocycline.