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Detection of halofantrine, mefloquine and proguanil by charge--transfer complexation on thin layer plates
M U Adikwu1, C O Esimone, A A Attama
1Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
Bollettino Chimico Farmaceutico
|June 1, 2000
Abstract:
A complexation phenomenon between certain antimalarials (as donors) and chloranilic acid (as an acceptor) has been studied using thin-layer-chromatography (TLC). The antimalarials were subjected to charge--transfer complexation using chloranilic acid as the pi-acceptor. This technique was used for the qualitative detection of the drugs. Drug-spotted TLC plates, when developed in suitable solvent systems and sprayed with the pi-acceptor gave a spontaneous purple colour. The Rr values of the three drugs were found to be constant and specific for each drug sample in a particular solvent system.