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Multiple drug resistant non typhoidal Salmonella spp associated with acute diarrheal disease
S Ananthan1, M Sheela, M A Subramanian
1Department of Microbiology, Dr. ALM No Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani.
Insights
Non-typhoidal Salmonella species were identified in 6% of children with acute diarrhea. Most isolates showed multidrug resistance but remained sensitive to Ciprofloxacin, highlighting treatment challenges.
Area of Science:
- Microbiology
- Pediatrics
- Infectious Diseases
Background:
- Acute diarrhea is a common childhood illness globally.
- Non-typhoidal Salmonella (NTS) species are significant enteric pathogens in children.
- Antimicrobial resistance in NTS complicates treatment strategies.
Purpose of the Study:
- To determine the prevalence of NTS in children with acute diarrhea.
- To identify specific NTS serotypes causing infections.
- To assess the antimicrobial resistance patterns of isolated NTS strains.
Main Methods:
- Rectal swabs and stool specimens were collected from 115 children aged 0-5 years with acute diarrhea.
- Specimens were screened for the presence of NTS.
- Antimicrobial susceptibility testing was performed on isolated NTS strains.
Main Results:
- Seven (6%) patients tested positive for NTS.
- Salmonella paratyphi B was identified in 4 (3.47%) cases, and Salmonella typhimurium in 3 (2.6%) cases.
- Multidrug resistance was observed in 57% of isolates. All strains were sensitive to Ciprofloxacin but resistant to Ampicillin.
Conclusions:
- NTS is an important cause of acute diarrhea in young children.
- High rates of multidrug resistance, particularly to Ampicillin, were found in NTS isolates.
- Ciprofloxacin remains a potential treatment option, but emerging resistance warrants continuous monitoring.
Abstract:
Rectal swabs/stool specimens from 115 children (0-5 years) suffering with acute diarrhea were screened for non typhoidal salmonella species. 7 (6%) patients were found to be positive for non typhoidal salmonella. 4 (3.47%) were positive for S. paratyphi B and 3 (2.6%) were positive for S. typhimurium. Multidrug resistance was seen in 57 percent of the strains. All strains were sensitive to Ciprofloxacin. All strains were resistant to Ampicillin followed by Ciprofloxacin. All strains were resistant to Ampicillin followed by Gentamycin (43%), Kanamycin (43%), Tetracycline (43%), Streptomycin (28.5%) and Chloramphenicol (28.5%).