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Vasculitis in children.

L Kumar1, S Singh

  • 1Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Indian Journal of Pediatrics
|May 1, 1996
PubMed
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Pediatric vasculitis, including Henoch-Schonlein purpura (HSP) and childhood polyarteritis nodosa (PAN), presents unique challenges in India. This study highlights severe gastrointestinal and renal issues in HSP and increased central nervous system involvement in PAN.

Area of Science:

  • Pediatric Rheumatology
  • Pediatric Vasculitis
  • Clinical Case Series

Background:

  • Vasculitis in children is rare, with limited data from India.
  • PGIMER, Chandigarh, has experience managing various pediatric vasculitides.

Purpose of the Study:

  • To provide an overview of vasculitides encountered in Indian children.
  • To review relevant literature and highlight specific findings.

Main Methods:

  • Retrospective review of pediatric vasculitis cases at PGIMER.
  • Analysis of clinical presentation, disease types, and outcomes.
  • Literature review for comparison.

Main Results:

  • Described 8 children with classical Polyarteritis Nodosa (PAN), noting frequent Central Nervous System (CNS) involvement.

Related Experiment Videos

  • Reported 10 cases of childhood BCPAN with severe peripheral gangrene and auto-amputation in 7.
  • Detailed 30 cases of Henoch-Schonlein Purpura (HSP) with high rates of gastrointestinal (86.7%) and severe renal involvement (nephrotic proteinuria 62%, azotemia 50%).
  • Observed delayed diagnosis in Kawasaki Disease.
  • Conclusions:

    • Pediatric vasculitis in India presents with distinct features, including severe complications.
    • Higher CNS involvement in PAN and severe gangrene in BCPAN noted.
    • HSP cases showed significant GI and renal morbidity, sometimes requiring surgical intervention.
    • Delayed diagnosis of Kawasaki Disease is a concern.