Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biliary atresia--the current management.

S Agarwala1, D K Mitra

  • 1Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi.

Indian Journal of Pediatrics
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis of extra pulmonary tuberculosis: An update on novel diagnostic approaches.

Respiratory medicine·2024
Same author

Stress resilience in patients with drug-resistant TB.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2023
Same author

Clinical Profile, Treatment, and Outcome of Patients with Secondary Hemophagocytic Lymphohistiocytosis in Critically Ill Patients: A Prospective Observational Study.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine·2022
Same author

Intracellular cytokine expression in invasive fungal sinusitis and its impact on patient outcome.

The Journal of laryngology and otology·2022
Same author

Accuracy of a convolutional neural network for dermatological diagnosis of tumours and skin lesions in a clinical setting.

Clinical and experimental dermatology·2021
Same author

Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same journal

A Prospective Model for Detecting Missed Appendicitis in Low-Risk Pediatric Patients: Correspondence.

Indian journal of pediatrics·2026
Same journal

Serum Periostin as a Biomarker in Pediatric Asthma: Findings from a Case-Control Study - Authors' Reply.

Indian journal of pediatrics·2026
Same journal

When the Eye Peels: An Unusual Harbinger of Kawasaki Disease - Correspondence.

Indian journal of pediatrics·2026
Same journal

Pediatric Sleep-Related Laryngospasm: Cause of Nocturnal Respiratory Distress.

Indian journal of pediatrics·2026
Same journal

Validation of DSD Interpreter, a Mobile Application for Point-of-Care Evaluation of Infants with Atypical Genitalia: Correspondence.

Indian journal of pediatrics·2026
Same journal

Prenatal Diagnosis and Genomics in India - Historical Review, Current Status and Road Ahead.

Indian journal of pediatrics·2026
See all related articles

Biliary atresia is an inflammatory process, not developmental. Early diagnosis and surgery improve outcomes, but liver transplantation is a viable option for advanced cases, despite challenges in India.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Hepatology

Background:

  • Biliary atresia (BA) remains a disease with ongoing controversies regarding its etiology, pathology, and management.
  • Current understanding suggests BA is a progressive panductal inflammatory obliterative process, distinct from a developmental anomaly.
  • Histologic changes in BA are similar to neonatal hepatitis, but certain features hold prognostic significance.

Purpose of the Study:

  • To review the current understanding of biliary atresia, including its diagnosis, management, and emerging treatment options.
  • To highlight the importance of early detection and surgical intervention for improving patient prognosis.
  • To discuss the role of liver transplantation as an alternative treatment for biliary atresia.

Main Methods:

Related Experiment Videos

  • Review of existing literature on biliary atresia, encompassing etiology, pathology, clinical presentation, diagnostic methods, and treatment outcomes.
  • Analysis of the effectiveness of surgical interventions like portoenterostomy (PE) and the emerging role of liver transplantation (LT).
  • Discussion of diagnostic tools including HIDA scans and operative cholangiograms.

Main Results:

  • Clinical presentation includes infantile obstructive cholangiopathy with jaundice, clay-colored stools, and dark urine.
  • Diagnosis is suggested by HIDA scan findings and confirmed operatively.
  • Early diagnosis and surgical treatment before two months of age are crucial for prognosis, though long-term results of bilioenteric drainage can be discouraging.

Conclusions:

  • Liver transplantation (LT) has emerged as a viable treatment option for biliary atresia, either primarily or after failed portoenterostomy (PE).
  • Despite available infrastructure, LT in children is not yet established in India due to economic and social factors.
  • Consideration of liver transplantation is recommended for physicians and surgeons managing biliary atresia patients.