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Hepatitis A in day care centre.

S D Chitambar1, M S Chadha, L R Yeolekar

  • 1National Institute of Virology, Pune.

Indian Journal of Pediatrics
|November 1, 1996
PubMed
Summary

A hepatitis A virus outbreak occurred in a Pune day-care center, infecting children and family contacts. Diagnostic tests confirmed Hepatitis A virus as the cause of the outbreak.

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Area of Science:

  • Epidemiology
  • Virology
  • Public Health

Background:

  • Focal outbreaks of hepatitis can occur in childcare settings.
  • Early identification and confirmation are crucial for controlling disease spread.

Purpose of the Study:

  • To investigate and confirm the causative agent of a hepatitis outbreak in a Pune day-care center.
  • To understand the transmission dynamics within the childcare and family settings.

Main Methods:

  • Clinical case identification and epidemiological investigation.
  • Serological testing for anti-hepatitis A virus IgM antibodies.
  • Molecular detection of hepatitis A virus RNA in stool samples using RT-nested PCR.

Main Results:

  • Seven out of 15 children in the day-care center developed hepatitis.
  • Two secondary cases were identified among family contacts.
  • All nine affected individuals tested positive for hepatitis A virus IgM antibodies, and HAV-RNA was detected in one stool sample.

Conclusions:

  • The outbreak was definitively caused by the hepatitis A virus (HAV).
  • Childcare centers can serve as focal points for HAV transmission.
  • Prompt laboratory confirmation is essential for effective outbreak management.

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