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Hypercoagulopathy with piperacillin administration in osteomyelitis
H Miyazaki1, S Yanagitani, T Matsumoto
1Third Department of Internal Medicine, Kansai Medical University, Osaka.
Abstract:
A 51-year-old man with osteomyelitis developed acute renal failure and superior mesenteric venous (SMV) thrombosis after piperacillin (PIPC) treatment. Coagulation profile disclosed disseminated intravascular coagulation (DIC). The serum levels of IgE and eosinophil cationic protein showed significant increases, while a lymphocyte stimulation test with PIPC also demonstrated an extremely high index. These observations suggest that hypersensitivity to PIPC might play a role in the pathogenesis of acute renal failure and SMV thrombosis due to hypercoagulopathy. Withdrawal of PIPC and anticoagulation therapy resulted in clinical improvement and normalization of the affected laboratory data. This is the first report to describe PIPC-induced hypercoagulopathy.
Insights
Piperacillin (PIPC) treatment may cause rare hypersensitivity reactions leading to hypercoagulopathy, acute renal failure, and thrombosis. Promptly stopping PIPC and initiating anticoagulation therapy improved patient outcomes.
Area of Science:
- Nephrology
- Hematology
- Clinical Immunology
Background:
- Piperacillin (PIPC) is an antibiotic commonly used for bacterial infections.
- Acute renal failure and venous thrombosis are serious potential complications of medical treatments.
- Disseminated intravascular coagulation (DIC) is a condition affecting blood clotting.