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Eosinophilic bronchopneumopathy in dogs
1Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Belgium. cclercx@ulg.ac.be
Journal of Veterinary Internal Medicine
|June 1, 2000
Summary
Eosinophilic bronchopneumopathy in young dogs presents with respiratory signs and characteristic airway inflammation. Diagnosis involves clinical signs, imaging, and cytology, with treatment typically including oral glucocorticoids.
Area of Science:
- Veterinary Medicine
- Pulmonology
- Immunology
Background:
- Eosinophilic bronchopneumopathy (EBP) is an inflammatory lung disease.
- This condition affects young dogs and can lead to significant respiratory compromise.
Purpose of the Study:
- To describe the clinical, diagnostic, and histopathologic features of EBP in a cohort of young dogs.
- To evaluate the treatment response to oral glucocorticoids.
Main Methods:
- Retrospective case series of 23 young dogs diagnosed with EBP.
- Evaluation of clinical signs, thoracic radiography, bronchoscopy, bronchoalveolar lavage cytology, bronchial biopsies, and serum immunoglobulin A levels.
- Treatment with alternate-day oral glucocorticoids with dose tapering.
Main Results:
- Common signs included cough, gagging, retching, and dyspnea.
- Radiographic findings showed bronchointerstitial patterns; bronchoscopy revealed mucus and mucosal thickening.
- Peripheral blood eosinophilia and eosinophils in airway cytology were frequent findings (61%).
- Histopathology confirmed eosinophilic infiltration of bronchial mucosa.
- Elevated serum immunoglobulin A was noted.
- Successful treatment with oral glucocorticoids was observed, though dosage varied.
Conclusions:
- Eosinophilic bronchopneumopathy in young dogs is characterized by specific clinical and diagnostic findings.
- Airway inflammation with eosinophilic infiltration is a key feature.
- Oral glucocorticoids appear effective for managing the condition.