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Related Concept Videos

Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
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Mouth Inspection
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Related Experiment Video

Updated: Jul 16, 2026

Quantification of Orofacial Phenotypes in Xenopus
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Craniofacial comparisons in 22-month-old lip-operated children with unilateral complete cleft lip and palate and

N V Hermann1, B L Jensen, E Dahl

  • 1Department of Pediatric Dentistry, School of Dentistry, University of Copenhagen, Denmark. nh@odont.ku.dk

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|June 1, 2000
PubMed
Summary

Infants with unilateral complete cleft lip and palate (UCCLP) show significant craniofacial differences compared to those with unilateral incomplete cleft lip (UICL) by 22 months of age. These differences, particularly in the maxilla and mandible, persist after early surgical repair.

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Area of Science:

  • Craniofacial surgery
  • Pediatric plastic surgery
  • Cleft lip and palate research

Background:

  • Early surgical intervention is standard for cleft lip and palate.
  • Understanding long-term craniofacial development is crucial for treatment planning.

Purpose of the Study:

  • To analyze and compare craniofacial morphology in infants with unilateral complete cleft lip and palate (UCCLP) and unilateral incomplete cleft lip (UICL).
  • To assess morphological changes following surgical closure at 2 months of age.

Main Methods:

  • Infant cephalometry using lateral, frontal, and axial projections.
  • Analysis of linear, angular, and area variables of craniofacial morphology.
  • Comparison of 108 children (UCCLP and UICL groups) at approximately 22 months of age.

Main Results:

  • Significant differences in facial morphology were observed between the UCCLP and UICL groups at 22 months.
  • The most pronounced differences were noted in the maxillary complex and mandible.
  • Observed deviations in the UCCLP group were similar to earlier findings but showed varying degrees of change over time.

Conclusions:

  • Early surgical repair does not eliminate craniofacial morphological differences between UCCLP and UICL.
  • Maxillary and mandibular development are significantly impacted by the type of cleft.
  • Ongoing monitoring and potential secondary interventions are important for managing craniofacial outcomes.