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Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques

O Tricot1, Z Mallat, C Heymes

  • 1Institut National de la Santé et de la Recherche Médicale, INSERM U541, Institut Fédératif de Recherche "Circulation," Hôpital Lariboisière, Paris, France.

Circulation
|June 1, 2000
PubMed
Summary

Endothelial cell apoptosis in human atherosclerosis primarily occurs downstream of plaques where blood flow and shear stress are low. This finding suggests shear stress influences plaque erosion and thrombosis.

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