Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transforming growth factor beta signaling mediators and modulators.

C M Zimmerman1, R W Padgett

  • 1Department of Molecular Biology and Biochemistry, and the Cancer Institute of New Jersey, Rutgers University, Piscataway 08854-8020, USA.

Gene
|June 1, 2000
PubMed
Summary

Transforming growth factor beta (TGFbeta) regulates cell fate and cell cycle. This study details the core TGFbeta pathway and its Smad protein modulators, crucial for diverse biological processes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New developments for TGFbeta.

Developmental cell·2001
Same author

Cost of diarrhea-associated hospitalizations and outpatient visits in an insured population of young children in the United States.

The Pediatric infectious disease journal·2001
Same author

SMA-3 smad has specific and critical functions in DBL-1/SMA-6 TGFbeta-related signaling.

Developmental biology·2000
Same author

TGFbeta signaling pathways and human diseases.

Cancer metastasis reviews·2000
Same author

Genetic approaches to TGFbeta signaling pathways.

Cytokine & growth factor reviews·2000
Same author

TGF beta-related pathways. Roles in Caenorhabditis elegans development.

Trends in genetics : TIG·2000

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Signaling

Background:

  • Transforming growth factor beta (TGFbeta) is a key regulator of diverse biological processes, including cell fate specification and cell cycle inhibition.
  • The TGFbeta signaling pathway is conserved across species and plays critical roles in development and homeostasis.

Purpose of the Study:

  • To elucidate the core TGFbeta signaling pathway.
  • To identify and describe proteins that modulate Smad activity and TGFbeta responses.

Main Methods:

  • Genetic and biochemical approaches were employed to dissect the TGFbeta signaling pathway.
  • Analysis focused on transmembrane receptors, Smad proteins, and their interactions.

Main Results:

Related Experiment Videos

  • The core TGFbeta pathway involves transmembrane receptors phosphorylating intracellular Smad proteins.
  • Phosphorylated Smads translocate to the nucleus to regulate transcription.
  • Numerous proteins interact with Smads, fine-tuning TGFbeta signaling.

Conclusions:

  • The TGFbeta pathway is a complex network involving Smad proteins as central mediators.
  • Modulators of Smad activity are critical for determining specific cellular responses to TGFbeta.
  • Understanding these modulators is essential for comprehending TGFbeta's multifaceted roles.