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Related Experiment Videos

Neonatal gram-negative bacteremia.

S G Joshi1, V S Ghole, K B Niphadkar

  • 1Department of Pathology, D.S.H. Medical College, Pune. molbio@chem.unipune.ernet.in

Indian Journal of Pediatrics
|June 1, 2000
PubMed
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Neonatal gram-negative bacteremia, particularly from Pseudomonas aeruginosa and Klebsiella pneumoniae, shows increasing antibiotic resistance. Effective treatment combines ampicillin-sulbactam with amikacin or ciprofloxacin.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Microbiology

Background:

  • Neonatal sepsis is a significant cause of mortality.
  • Gram-negative bacteremia poses a substantial threat in Neonatal Intensive Care Units (NICUs).
  • Understanding antibiotic resistance patterns is crucial for effective treatment.

Purpose of the Study:

  • To determine the incidence of neonatal gram-negative bacteremia.
  • To investigate the antibiotic resistance patterns of common gram-negative isolates.
  • To identify effective antibiotic combinations for treatment.

Main Methods:

  • A 22-month prospective study of 1326 clinically suspected neonatal sepsis cases.
  • Microbiological analysis to identify causative agents and determine antibiotic susceptibility.

Related Experiment Videos

  • Analysis of patient demographics, underlying conditions, and sources of infection.

    • Main Results:

    • Gram-negative bacteremia was confirmed in over 25% of sepsis cases.
    • Predominant isolates included Pseudomonas aeruginosa (38.3%) and Klebsiella pneumoniae (30.4%).
    • High resistance rates were observed for extended-spectrum cephalosporins, piperacillin, and gentamicin.
    • Mortality rate was 32%, associated with neutropenia, nosocomial infections, and inappropriate therapy.
    • Ampicillin-sulbactam combined with amikacin or ciprofloxacin showed the highest sensitivity.

    Conclusions:

    • Pseudomonas aeruginosa and Klebsiella pneumoniae are leading causes of neonatal gram-negative bacteremia.
    • Increasing antibiotic resistance necessitates careful selection of empirical therapy.
    • Combination therapy with ampicillin-sulbactam and either amikacin or ciprofloxacin is recommended for effective treatment.