Activity of nonsteroid anti-inflammatory drugs in immunologically specific and nonspecific cellular responses

The influence of nonsteroid anti-inflammatory drugs on immunologic reactions of the humoral type (agglutinins, hemolysins) and of the cellular types (blast test, transplantation test), and on the course of immunologically nonspecific inflammatory reactions(xylene inflammation, pleurisy, granulation test) has been studied. Virtually regardless of chemical structure (indomethacin, mefenamic acid, acetylsalicylic acid, chloroquine), the drugs of this group had no influence on humoral responses, but a distinct influence on the delayed type of cellular responses and on immunologically nonspecific reactions. The investigated drugs had quantitatively varying modes of action, and only chloroquine showed a qualitatively different mode of action. It was concluded that nonsteroid anti-inflammatory drugs ace on a common link in inflammatory processes involving the immunologic system, as well as without such an involvement. The mechanism of their effect was considered to consist in stabilization of cell membranes, inhibition of proliferation and cellular transformation, and inhibition of the lymph node permeability factor (LNPF).