[Normal NO synthases and in pathology of different origins]

The paper deals with the physicochemical properties of nitric oxide (NO) and with the mechanisms of its action and synthesis in man and animals. The cytotoxic, vasodilatory, neuromediator, and other properties of NO are analyzed. NO is shown to perform many functions in health and in diseases of various genesis. Analyzing the structure and functions of NO in health and in diseases suggests that they all have both structural and functional properties and their own features. The currently available data lead to the conclusion that the NO-synthase mechanism that is responsible for the production of NO is its synthesis in the presence of oxygen. During functional exercises and hypoxia of various origin, another mechanism of NO may become active, which is associated with the reduction of NO2- in NO.