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Updated: Jul 1, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Congenital deficiency of factor VII.

M Sikka¹, S Gomber, N Madan

¹Department of Pathology, UCMS & GTB Hospital, Shahdara, Delhi.

Indian Journal of Pediatrics

|July 1, 1996

Summary

This summary is machine-generated.

Congenital factor VII deficiency, a rare bleeding disorder, was diagnosed in a five-year-old child presenting with recurrent epistaxis. The child is reportedly doing well under medical observation.

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Area of Science:

Hematology
Pediatric Medicine
Rare Bleeding Disorders

Background:

Congenital factor VII deficiency is a rare inherited bleeding disorder.
It is caused by mutations in the F7 gene, leading to reduced levels or activity of coagulation factor VII.
Clinical manifestations can range from mild bruising to severe hemorrhage.

Observation:

A five-year-old child with a history of recurrent epistaxis was evaluated.
The patient was born into a non-consanguineous marriage.
Initial laboratory tests revealed a markedly prolonged prothrombin time (PT).

Findings:

Bleeding time (BT), partial thromboplastin time with Kaolin (PTTK), and platelet count were within normal limits.
These findings are consistent with isolated factor VII deficiency.
The diagnosis was confirmed in the pediatric patient.

Implications:

Early diagnosis and management are crucial for preventing severe bleeding complications.
Factor replacement therapy or other hemostatic agents can be used for treatment.
This case highlights the importance of considering rare bleeding disorders in children with unexplained bleeding symptoms.