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Quinolones and tendon ruptures.

J M Casparian1, M Luchi, R E Moffat

  • 1Department of Medicine, University of Kansas Medical Center, Kansas City 66160-7319, USA.

Southern Medical Journal
|June 1, 2000
PubMed
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Ciprofloxacin, a fluoroquinolone antibiotic, is linked to tendon ruptures, even with minor stress. This study highlights the increased risk of Achilles and subscapularis tendon injuries associated with fluoroquinolone use.

Area of Science:

  • Pharmacology
  • Orthopedic Surgery
  • Rheumatology

Background:

  • Fluoroquinolones are broad-spectrum antibiotics with known side effects.
  • Tendon rupture is a serious adverse event that can lead to significant morbidity.

Observation:

  • Two cases of tendon rupture (Achilles and subscapularis) occurred after ciprofloxacin use.
  • Ruptures happened with minimal mechanical stress, suggesting drug-induced susceptibility.

Findings:

  • Ciprofloxacin use may increase the risk of spontaneous tendon rupture.
  • Literature review supports an association between fluoroquinolones and tendon pathologies.

Implications:

  • Clinicians should consider the risk of tendon rupture when prescribing fluoroquinolones.

Related Experiment Videos

  • Patients on fluoroquinolones should be aware of potential tendon-related symptoms.