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Orthodontic tooth movement in the prednisolone-treated rat
The Angle Orthodontist
|June 1, 2000
Summary
Corticosteroid treatment, like prednisolone, did not alter orthodontic tooth movement magnitude. However, it significantly reduced root resorption and suppressed clastic activity in rats, indicating a localized effect on bone remodeling during orthodontic treatment.
Area of Science:
- Orthodontics
- Endocrinology
- Bone Biology
Background:
- Corticosteroids are known to affect bone metabolism.
- Concerns exist regarding their potential impact on orthodontic tooth movement.
- Understanding this interaction is crucial for patient treatment planning.
Purpose of the Study:
- To investigate the effect of prednisolone on orthodontic tooth movement in a rat model.
- To assess the influence of corticosteroids on root resorption and cellular activity during tooth movement.
Main Methods:
- A rat model was used with two groups: corticosteroid-treated (prednisolone) and control (saline).
- An orthodontic appliance applied mesial force to the maxillary first molar.
- Tooth movement, root resorption, and tartrate-resistant acid phosphatase (TRAP) activity were measured.
Main Results:
- No significant difference in the magnitude of tooth movement was observed between groups.
- Corticosteroid-treated rats showed significantly reduced root resorption on the compression side.
- Fewer TRAP-positive cells, indicative of osteoclast activity, were found in the periodontal ligament of steroid-treated rats.
Conclusions:
- Prednisolone treatment does not impede the overall rate of orthodontic tooth movement.
- Corticosteroids appear to suppress clastic activity, leading to decreased root resorption during orthodontic treatment.
- This suggests a localized anti-resorptive effect of steroids on the compression side of the moving tooth.