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Surgeon scientist.

J E Murray1

  • 1Department of Surgery, Brigham and Women's Hospital, Children's Hospital, Wellesley Hills, MA 02481, USA. josmurray@aol.com

World Journal of Surgery
|June 1, 2000
PubMed
Summary
This summary is machine-generated.

The Brigham

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Area of Science:

  • Nephrology
  • Surgical Innovation
  • Transplantation

Background:

  • The renal transplant program at Peter Bent Brigham Hospital began in the late 1940s.
  • Initial research focused on hypertension as a cause of renal failure.
  • Early experiments involved unmodified allogeneic grafts and canine studies.

Observation:

  • The first successful human kidney transplant between identical twins occurred in 1954.
  • A successful fraternal allogeneic graft was achieved in 1959 using total body irradiation and bone marrow replacement.
  • The first successful cadaveric kidney transplant was performed in 1962 following the development of immunosuppressive drugs.

Findings:

  • The program evolved from understanding renal failure causes to successful human transplantation.

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  • Key milestones include successful identical twin, fraternal allogeneic, and cadaveric kidney transplants.
  • Advancements in immunosuppression were critical for later transplant successes.

    • Implications:

    • This work significantly advanced the field of organ transplantation globally.
    • It laid the foundation for current multi-organ transplant programs (kidney, liver, heart, etc.).
    • The program's history highlights the progression from basic research to life-saving clinical practice.