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Tolerance and its clinical significance.

L B Brent

    World Journal of Surgery
    |June 1, 2000
    PubMed
    Summary

    Inducing specific tolerance is key for successful organ transplantation. Researchers explore various strategies, including bone marrow augmentation and novel antibody treatments, to overcome immune rejection in patients.

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    Area of Science:

    • Immunology
    • Transplantation Science

    Background:

    • Immune tolerance is crucial for successful organ transplantation.
    • Current methods often face challenges with immune rejection.

    Purpose of the Study:

    • To review and discuss strategies for inducing specific immune tolerance in adult animals and patients.
    • To highlight potential solutions for allogeneic and xenogeneic transplantation challenges.

    Main Methods:

    • Discussion of established and novel tolerance induction strategies.
    • Review of techniques including bone marrow augmentation, monoclonal antibody therapy, linked epitope suppression, and mixed chimerism.
    • Consideration of approaches like total lymphoid irradiation and intrathymic induction.

    Main Results:

    • Several promising strategies for specific tolerance induction are identified.
    • These methods aim to prevent immune rejection in organ transplantation.

    Conclusions:

    • Specific tolerance induction remains the most desirable solution for allogeneic and xenogeneic transplantation.
    • Further research and clinical application of these strategies are anticipated.

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