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Double role of HLA in organ transplantation
1Europdonor Foundation, Leiden University Medical Centre, Leiden, The Netherlands. vanrood@rullf2.leidenuniv.nl
Although HLA matching can improve organ graft survival, well matched grafts fail and poorly matched ones survive. Recently evidence has been found that perinatal exposure to noninherited antigens (NIMAs) has a lifelong impact on the immune repertoire of the individual. The state of the art of the influence of NIMAs on graft survival is summarized. These findings could lead to a better understanding of the allograft reaction.
Although HLA matching can improve organ graft survival, well matched grafts fail and poorly matched ones survive. Recently evidence has been found that perinatal exposure to noninherited antigens (NIMAs) has a lifelong impact on the immune repertoire of the individual. The state of the art of the influence of NIMAs on graft survival is summarized. These findings could lead to a better understanding of the allograft reaction.