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Related Experiment Videos

Spinal cord microstimulation generates functional limb movements in chronically implanted cats.

V K Mushahwar1, D F Collins, A Prochazka

  • 1Division of Neuroscience, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada.

Experimental Neurology
|June 2, 2000
PubMed
Summary
This summary is machine-generated.

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Effect of cervicolumbar coupling on spinal reflexes during cycling after incomplete spinal cord injury.

Journal of neurophysiology·2018

Researchers developed a new method using tiny implanted electrodes to stimulate the spinal cord, successfully restoring coordinated hindlimb movements in cats. This offers hope for spinal cord injury recovery and mobility restoration.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Spinal cord injuries sever brain-to-body communication, but lower spinal neurons remain functional.
  • Restoring function requires artificial stimulation of intact neural circuits below the lesion.
  • Existing methods face challenges in long-term efficacy and invasiveness.

Purpose of the Study:

  • To investigate a novel approach for generating functional movements via spinal cord electrical stimulation.
  • To assess the feasibility and efficacy of chronically implanted ultrafine electrodes for motor control.
  • To evaluate the stability and safety of spinal cord neuroprostheses.

Main Methods:

  • Implantation of 6-12 ultrafine, hair-like microwire electrodes into the lumbar enlargement of intact cats.

Related Experiment Videos

  • Chronic implantation for 6 months with regular stimulation sessions.
  • Delivery of electrical stimuli trains through individual microwires.
  • Recording of evoked electromyographic and joint torque responses.

    • Main Results:

    • Strong, coordinated hindlimb movements were consistently elicited through individual electrode stimulation.
    • Elicited joint torques were sufficient to support the animals' hindquarters.
    • Responses remained stable over the 6-month implantation period.
    • No apparent discomfort or motor deficits were observed in the animals.

    Conclusions:

    • Ultrafine microwire electrodes can be stably implanted in the spinal cord for extended periods.
    • Electrical stimulation through these electrodes effectively produces strong and controllable movements.
    • This technology presents a promising foundation for developing spinal cord neuroprostheses to restore mobility after injury.