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[Vasoactive intestinal peptide in heart failure].

P Lucia1, S Caiola, A Coppola

  • 1II Clinica Medica, Università degli Studi La Sapienza, Roma.

Italian Heart Journal. Supplement : Official Journal of the Italian Federation of Cardiology
|June 2, 2000
PubMed
Summary

Vasoactive intestinal peptide (VIP) levels in heart failure patients are influenced by age and clinical status. While initially elevated to support hemodynamics, VIP may deplete in advanced heart failure.

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Area of Science:

  • Cardiology
  • Neuropeptide Research
  • Heart Failure Pathophysiology

Background:

  • Vasoactive intestinal peptide (VIP) is a neuropeptide with vasodilating, inotropic, and chronotropic effects.
  • Its role in the pathophysiology of heart failure requires further investigation.

Purpose of the Study:

  • To investigate the pathophysiological role of vasoactive intestinal peptide (VIP) in patients with heart failure.

Main Methods:

  • Radioimmunoassay of VIP in peripheral venous blood samples.
  • Study included 35 patients with heart failure due to dilated cardiomyopathy.

Main Results:

  • Plasma VIP concentrations were not elevated in the overall heart failure group compared to normal.
  • VIP levels varied with age and NYHA functional class, showing preservation in elderly patients.

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  • No correlation was found between VIP levels and echocardiographic parameters or cardiomyopathy etiology.

    • Conclusions:

    • Plasma VIP concentration in heart failure is influenced by epidemiological and clinical factors.
    • The neuropeptide's productive potential is preserved in elderly heart disease patients.
    • Elevated VIP may initially aid hemodynamic balance, while decreased levels in worse conditions suggest depletion.