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The genetics of multiple sclerosis
1University of Cambridge Neurology Unit, Addenbrooke's Hospital, UK.
Clinical Chemistry and Laboratory Medicine
|June 2, 2000
Abstract:
Classical genetic studies involving the analysis of pedigrees and recurrence risk within families have defined the extent to which genetic factors contribute to the aetiology of multiple sclerosis. Limited progress has been made in identifying the number and topography of genetic loci contributing to susceptibility through molecular investigation either of candidate genes or the whole genome using microsatellite and single nucleotide polymorphisms.