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Depersonalization in panic disorder: a clinical study.

J Seguí¹, M Márquez, L García

¹Section of Psychiatry, La Alianza General Hospital, Barcelona, Spain.

Comprehensive Psychiatry

|June 2, 2000

Summary

Panic disorder (PD) is heterogeneous. Patients experiencing depersonalization during panic attacks are younger, have earlier onset, and more severe symptoms, suggesting a distinct PD subtype.

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Area of Science:

Psychiatry
Clinical Psychology
Neuroscience

Background:

Panic disorder (PD) is considered heterogeneous.
Depersonalization during panic attacks may indicate a distinct PD subgroup.

Purpose of the Study:

To analyze the differential features of PD patients with depersonalization.
To investigate if depersonalization constitutes a unique PD subtype.

Main Methods:

274 PD patients were assessed using the Structured Clinical Interview for DSM-III-R (SCID-UP-R).
Patients were divided into groups based on the presence or absence of depersonalization.
Clinical scales included Hamilton Anxiety and Depression Rating Scale (HARS/HDRS), Marks and Mathews Fears and Phobia Scale, and Panic-Associated Symptom Scale (PASS).

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Main Results:

66 patients (24.1%) reported depersonalization during panic attacks.
The depersonalization group was younger with an earlier age of onset.
This group exhibited more severe PD, including more attacks, worse functioning, and higher symptom scores.
Increased comorbidity with specific phobia was observed in the depersonalization group.

Conclusions:

Depersonalization during panic attacks may define a distinct and more severe subtype of Panic Disorder.
Findings support the heterogeneity of PD and the clinical significance of depersonalization.