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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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NK cells, anti-tumor surveillance and interleukins.

Immunology today·2014

Same author

TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset.

Journal of immunology (Baltimore, Md. : 1950)·2000

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Cell cycle-dependent tumor necrosis factor apoptosis.

Cancer research·1996

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Uncoupling IL-2 production from apoptosis and TNF production by changing the signal through the TCR.

Journal of immunology (Baltimore, Md. : 1950)·1996

Same author

Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation.

Journal of immunology (Baltimore, Md. : 1950)·1993

Same author

H-2 I-E molecules isolated from Mls1a stimulatory cells do not activate Mls1a-responsive T cells but do present exogenous staphylococcal enterotoxins.

European journal of immunology·1993

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[Immunology of the future].

¹Memorial Sloan Kettering Cancer Center, New York, USA. ostutman@hotmail.com

|June 3, 2000

Summary

Immunology, a young science, has significantly advanced basic biology. Future research will focus on homeostasis, antigen presentation, and cell interactions, leading to new immunological therapies for diseases.

Area of Science:

Modern immunology, rooted in T and B cell receptor discoveries of the 70s-80s.
A relatively young field that has driven advances in signal transduction, apoptosis, and cell cycle regulation.

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