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[Hepatotoxicity by amoxicillin/clavulanic acid: case report]
A Soza1, F Riquelme, M Alvarez
1Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile.
Revista Medica De Chile
|June 3, 2000
Summary
A 72-year-old diabetic male developed jaundice and itching after amoxicillin-clavulanic acid use. Ursodeoxycholic acid improved liver function, suggesting its potential for treating drug-induced cholestasis.
Area of Science:
- Hepatology
- Pharmacology
- Internal Medicine
Background:
- Drug-induced liver injury (DILI) is a significant clinical concern.
- Amoxicillin-clavulanic acid is a common antibiotic associated with various adverse effects.
- Cholestatic hepatitis is a pattern of liver injury characterized by impaired bile flow.
Observation:
- A 72-year-old male with diabetes mellitus presented with pruritus and jaundice post-amoxicillin-clavulanic acid administration.
- Liver function tests revealed elevated bilirubin, AST, ALT, and alkaline phosphatase levels.
- Hepatitis A, B, C serology and ERCP were unremarkable; liver biopsy confirmed cholestatic hepatitis.
Findings:
- Amoxicillin-clavulanic acid was identified as the likely causative agent for drug-induced cholestatic hepatitis.
- Treatment with ursodeoxycholic acid led to symptomatic improvement (pruritus) and normalization of liver function tests.
- This case highlights a specific DILI presentation and a potential therapeutic option.
Implications:
- Ursodeoxycholic acid may be a beneficial treatment for amoxicillin-clavulanic acid-induced cholestatic hepatitis.
- Clinicians should consider DILI in patients presenting with liver abnormalities after antibiotic use.
- Further research is warranted to establish the efficacy of ursodeoxycholic acid in DILI.