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Updated: Jul 31, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Hepatic malignancies

J I Tsao1, J DeSanctis, R L Rossi

  • 1Department of Surgery, Tufts University School of Medicine, Burlington, Massachusetts, USA.

The Surgical Clinics of North America
|June 3, 2000
PubMed

Insights

Despite advances in liver cancer treatment, recurrence remains a major challenge. Ongoing laboratory research into molecular and genetic factors offers hope for improved therapies and patient survival.

Area of Science:

  • Hepatobiliary Malignancies
  • Cancer Research
  • Molecular Oncology

Background:

  • Significant progress in liver cancer treatment over the last decade, including diagnostics, surgical resection, ablative therapies, and multimodal approaches.
  • Despite advancements, over 70% of treated patients experience recurrence, leading to mortality.
  • Liver cancer recurrence remains a critical unmet need in oncology.

Purpose of the Study:

  • To review current therapeutic strategies for liver malignancies.
  • To highlight the persistent challenge of tumor recurrence after treatment.
  • To emphasize the importance of ongoing laboratory research for future therapeutic development.

Main Methods:

  • Review of recent advancements in liver cancer diagnostics and treatment modalities.
  • Analysis of recurrence patterns and outcomes in treated patients.
  • Exploration of current laboratory investigations into cancer pathophysiology.

Main Results:

  • Current treatments have improved but have not eradicated the problem of liver cancer recurrence.
  • Laboratory research is actively investigating the molecular and genetic underpinnings of liver cancer.
  • Understanding cancer emergence and spread is key to developing novel therapies.

Conclusions:

  • Liver cancer recurrence remains a significant cause of mortality despite therapeutic progress.
  • Further research into molecular and genetic mechanisms is crucial for advancing treatment.
  • Future therapies hold promise for improving disease-free survival in liver cancer patients.

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