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Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
Published on: April 21, 2014
Mitral valve repair and septal myectomy for hypertrophic obstructive cardiomyopathy
Y Matsui1, N Shiiya, T Murashita
1Department of Cardiovascular Surgery, Hokkaido University, Sapporo, Japan.
Insights
This study shows that combining septal myectomy with sliding leaflet mitral valve repair effectively treats hypertrophic obstructive cardiomyopathy (HOCM). This surgical approach significantly reduces left ventricular outflow tract (LVOT) obstruction and mitral regurgitation.
Area of Science:
- Cardiology
- Cardiac Surgery
- Cardiovascular Research
Background:
- Hypertrophic obstructive cardiomyopathy (HOCM) can cause severe left ventricular outflow tract (LVOT) obstruction and mitral regurgitation.
- Medical management for HOCM symptoms, including congestive heart failure, is often insufficient.
- Severe cases necessitate surgical intervention to alleviate obstruction and valve dysfunction.
Abstract:
Combined mitral valve repair using the sliding leaflet technique and septal myectomy were employed to successfully treat left ventricular outflow tract (LVOT) obstruction and mitral regurgitation due to hypertrophic obstructive cardiomyopathy (HOCM). A 46-year-old man was diagnosed with HOCM along with congestive heart failure and was treated medically. These symptoms, however, were resistant to medical treatments with a beta-blocker, a Ca-antagonist, and disopyramide, and he was referred to our hospital for surgery. Doppler echocardiography demonstrated an LVOT obstruction at rest with a peak pressure gradient of 138 mmHg. The interventricular septum thickness was 14 mm. Mitral regurgitation of 3+ with severe SAM was also observed. Temporary dual chamber pacing was tried without significant improvement. Following these examinations, the patient underwent surgery. A transaortic septal myotomy-myectomy was performed first, and the mitral valve was then approached through the left atrium. Mitral valve repair was performed with the sliding leaflet technique to reduce the height of the posterior leaflet from 2 cm to 1 cm. Postpump transesophageal echocardiography revealed no MR and a peak LVOT gradient of 15 mmHg. The patient recovered well except for a residual mild SAM, and MR2+. We therefore concluded that this surgical approach might provide results which are superior to those of myectomy alone.
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