Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Roles for Fgf signaling during zebrafish fin regeneration.

K D Poss1, J Shen, A Nechiporuk

  • 1Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah Health Sciences Center, 15N 2030E, Salt Lake City, Utah, 84112, USA.

Developmental Biology
|June 6, 2000
PubMed
Summary

Fibroblast growth factors (FGFs) are crucial for zebrafish fin regeneration. FGF signaling initiates blastema formation and promotes cell proliferation and outgrowth, essential for limb and fin regrowth.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A review of a perinatal genetics and genomics service's role in prenatal diagnosis.

Irish medical journal·2026
Same author

The Cxcl14 chemokine defines pioneer axon guidance and early circuit assembly in the inner ear.

bioRxiv : the preprint server for biology·2026
Same author

Precarious migrants and COVID-19 responses: leave no one behind.

Public health·2022
Same author

High-Resolution Multi-Isotope Imaging Mass Spectrometry (MIMS) Imaging Applications in Stem Cell Biology.

Current protocols·2021
Same author

Livestock microbial landscape patterns: Retail poultry microbiomes significantly vary by region and season.

Food microbiology·2021
Same author

Applying the British Association of Oral and Maxillofacial Surgeons quality outcomes metrics to a UK oncology and reconstructive surgery service - benchmarking the data.

The British journal of oral & maxillofacial surgery·2021

Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Blastema formation is critical for urodele limb and teleost fin regeneration.
  • The role of fibroblast growth factors (Fgfs) in initiating blastema formation requires further investigation.

Purpose of the Study:

  • To investigate the role of fibroblast growth factors (Fgfs) in zebrafish caudal fin regeneration.
  • To determine if Fgfs initiate blastema formation from fin mesenchyme.

Main Methods:

  • Utilized the zebrafish caudal fin regeneration model.
  • Examined fibroblast growth factor receptor 1 (fgfr1) and wfgf expression patterns.
  • Applied a specific Fgfr1 inhibitor to assess its effects on blastema formation and regeneration.

Related Experiment Videos

Main Results:

  • Fgfr1 is expressed in mesenchymal cells during blastema formation and regenerative outgrowth.
  • A specific Fgfr1 inhibitor blocked blastema formation, cell proliferation, and msx gene transcription.
  • Inhibiting Fgf signaling during regeneration halted outgrowth and downregulated msx and sonic hedgehog expression.

Conclusions:

  • Fibroblast growth factor (FGF) signaling is essential for zebrafish fin blastema formation.
  • FGF signaling plays a critical role in regenerative outgrowth, regulating cell proliferation and gene expression.