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Detailed allelic loss mapping on 7q32 in nasopharyngeal carcinoma
1Cancer Research Institute, Hunan Medical University, Changsha, Hunan, 410078 P. R. China. ligy@public.cs.hn.cn
Abstract
Objective:
The present research group had found high frequency of loss of heterozygosity(LOH) of D7S500-D7S495 on chromosome band 7q32 in nasopharyngeal carcinoma, this study was conducted to further find the deletion region.
Methods:
Higher density of loci on 7q32 in 30 tumors was studied by using microsatellite analysis.
Results:
The frequency of LOH was 63.3%. The highest frequency of LOH was identified at the loci of D7S500-D7S509-D7S495, among which a common deletion of D7S509 was found.
Conclusion:
A putative tumor suppressor gene may be present around D7S509.