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Genetic heterogeneity of non-specific mental retardation
1Department of Medical Genetics, Shandong Medical University, Jinan, Shandong, 250012 P. R. China. chenjie81@163.net
Objective:
To explore genetic patterns of non-specific mental retardation (NSMR).
Methods:
Using segregation analysis, Finney method and Falconer method, the authors studied 157 pedigrees with NSMR selected in a population survey in Shandong province.
Results:
Ux U multiplex families may accept the autosomal recessive inheritance, Ux U total families is the autosomal recessive inheritance while it may be the multifactorial inheritance with major-gene effect, the frequency of sporadic cases is approximately 46%; Ux A mating families may keep the incomplete penetrance in autosomal dominant inheritance.
Conclusion:
The genetic pattern of NSMR has the genetic heterogeneity.