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Related Experiment Videos

Host response to tissue engineered devices.

Mikos1, McIntire, Anderson

  • 1Cox Laboratory for Biomedical Engineering, Institute of Biosciences and Bioengineering, Rice University, 6100 South Main, Houston, TX 77005, USA

Advanced Drug Delivery Reviews
|June 6, 2000
PubMed
Summary
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Tissue engineered devices rely on biomaterials and transplanted cells. Host responses to both components critically influence device success, impacting inflammation and immune rejection for better tissue regeneration.

Area of Science:

  • Biomaterials Science
  • Immunology
  • Tissue Engineering

Background:

  • Tissue engineered devices integrate biomaterials and cells for tissue/organ restoration.
  • Host responses to biomaterials and transplanted cells determine device biocompatibility.
  • Understanding these interactions is crucial for successful tissue regeneration.

Purpose of the Study:

  • To review the inflammatory response to biomaterials and immune response to transplanted cells in tissue engineering.
  • To emphasize how cell constructs influence host responses.
  • To explore the interplay between biomaterial inflammation and cellular immune responses.

Main Methods:

  • Literature review of inflammatory and immune responses in tissue engineering.
  • Analysis of host responses to polymer scaffolds and cell constructs.

Related Experiment Videos

  • Examination of immune mechanisms against allografts and xenografts.

    • Main Results:

    • Inflammatory responses to biomaterials can affect immune responses to cells, and vice versa.
    • Immune rejection is a primary concern for allogeneic, xenogeneic, or manipulated autologous cells.
    • Antigen shedding and indirect antigen presentation are key in immune responses to encapsulated cells.

    Conclusions:

    • Biocompatibility hinges on the interplay between host inflammatory and immune responses to device components.
    • Biodegradable polymer scaffolds show varied inflammatory profiles.
    • Successful integration of devices for bone, nerve, and skin regeneration depends on managing immune responses to encapsulated cells.