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Somatotropin delivery to farmed animals
1Pharmaceutical Development, Pharmacia and Upjohn, Inc., Kalamazoo, MI, USA
Advanced Drug Delivery Reviews
|June 6, 2000
Summary
Developing effective somatotropin formulations for farmed animals like cows and swine is challenging due to stability issues. This review covers formulation strategies to improve delivery and discusses future applications of somatotropin.
Area of Science:
- Animal Science
- Biotechnology
- Pharmaceutical Sciences
Background:
- Bovine somatotropin (bST) enhances milk production in cows; porcine somatotropin (pST) promotes growth in swine.
- Somatotropin formulation is complex due to its physicochemical properties and rapid in vivo clearance.
Purpose of the Study:
- To review the current status of somatotropin delivery systems in farmed animals.
- To summarize formulation challenges and approaches for somatotropin.
- To discuss future applications of somatotropin in animal agriculture.
Main Methods:
- Review of scientific literature on somatotropin formulation and delivery.
- Analysis of physicochemical properties influencing formulation design.
- Summary of various controlled-release formulation strategies.
Main Results:
- Key challenges include somatotropin's heat/enzyme lability, aggregation, pH-dependent stability, and rapid clearance.
- Excipients and vehicles partially address chemical and physical stability issues.
- Formulations like implants, oleaginous suspensions, and microparticles prolong somatotropin release.
Conclusions:
- Overcoming somatotropin's inherent instability is crucial for effective animal delivery.
- Advanced formulation techniques are essential for optimizing somatotropin's therapeutic effects in livestock.
- Further research into novel delivery systems will expand somatotropin's utility in animal production.
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