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Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
Published on: July 23, 2016
Cytosolic drug delivery using pH- and light-sensitive liposomes
Advanced Drug Delivery Reviews
|June 6, 2000
Summary
Researchers reviewed novel liposome drug delivery methods from 1995-1997. These included antibody targeting and triggered release mechanisms to enhance drug effectiveness and reduce side effects.
Area of Science:
- Drug Delivery and Pharmaceutical Sciences
- Biotechnology and Biomedical Engineering
Background:
- Liposomes are widely investigated for drug encapsulation to improve therapeutic outcomes.
- Enhancing drug localization and controlled release is crucial for optimizing the therapeutic index of liposomal drugs.
Purpose of the Study:
- To review literature from January 1995 to December 1997 on novel liposome targeting and content release strategies.
- To highlight advancements in antibody/receptor-mediated targeting and triggered release mechanisms for improved drug delivery.
Main Methods:
- Literature review of scientific publications between January 1995 and December 1997.
- Categorization of studies based on targeting strategies (antibody/receptor-mediated) and release triggers (acid, enzymatic, thermal, photochemical).
Main Results:
- Identification of antibody and receptor-mediated approaches for enhanced drug targeting to specific sites.
- Analysis of various triggering mechanisms (acid, enzymatic, thermal, photochemical) that destabilize liposomal membranes.
- Demonstration of improved drug bioavailability through enhanced cytoplasmic delivery.
Conclusions:
- Novel targeting and triggered release systems show significant potential for improving liposomal drug delivery.
- These advanced strategies enhance drug localization and bioavailability, leading to a better therapeutic index.
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