Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Secondary immunodeficiency in miliary tuberculosis.

S Uberoi, A N Malaviya, C Chattopadhyay

    Clinical and Experimental Immunology
    |December 1, 1975
    PubMed
    Summary

    Patients with miliary tuberculosis exhibit significant secondary immunodeficiency, indicated by impaired cell-mediated immune responses. Treatment with chemotherapy improved these immune responses, suggesting a reversible condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    To Treat or Not to treat Asymptomatic Hyperuricemia.

    The Journal of the Association of Physicians of India·2021
    Same author

    The human immunodeficiency virus and the healthcare worker.

    The National medical journal of India·2018
    Same author

    Rheumatology-Specific Electronic Health Record Software: Comment on the Article by Newman et al.

    Arthritis care & research·2015
    Same author

    Mustard aphid infestation in India: development of forewarning models.

    Journal of environmental biology·2014
    Same author

    Psoriatic arthritis screening tools: study design and methodologic challenges - reply from authors.

    The British journal of dermatology·2014
    Same author

    Comparison of three screening tools to detect psoriatic arthritis in patients with psoriasis (CONTEST study).

    The British journal of dermatology·2013

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Mycobacterial Infections

    Background:

    • Miliary tuberculosis (TB) is a severe disseminated form of TB.
    • Cell-mediated immunity plays a crucial role in controlling TB.
    • The immune status of patients with miliary TB requires further elucidation.

    Purpose of the Study:

    • To investigate the cell-mediated immune response in patients with miliary tuberculosis.
    • To assess the impact of chemotherapy on immune function in these patients.

    Main Methods:

    • Evaluated delayed hypersensitivity skin tests using purified protein derivative (PPD) and streptokinase-streptodornase (SKSD).
    • Assessed non-specific inflammatory response and contact sensitivity using 2,4-dinitrochlorobenzene (DNCB).
    • Performed leukocyte migration inhibition tests with Mycobacterium tuberculosis.
    • Quantified E rosette-forming cells and EAC rosette-forming cells.

    Main Results:

    • Delayed hypersensitivity skin tests were largely negative (2/15 for PPD, 1/15 for SKSD).
    • DNCB failed to induce inflammatory response or sensitization in most patients (13/15).
    • Leukocyte migration inhibition was observed in 8/11 patients.
    • A significant depression in E rosette-forming cells was noted, while EAC rosette-forming cells remained normal.
    • Following chemotherapy, 4/5 patients showed improved PPD and DNCB responses.

    Conclusions:

    • Miliary tuberculosis is associated with a marked secondary immunodeficiency, particularly affecting cell-mediated immunity.
    • Chemotherapy and clinical improvement can lead to the restoration of certain immune functions.
    • These findings highlight the immune dysregulation in severe TB and its potential reversibility.

    Related Experiment Videos