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The human dopamine D2(Longer) receptor has a high-affinity state and inhibits adenylyl cyclase
I S Liu1, S R George, P Seeman
1Department of Pharmacology, Medical Sciences Building, 8 Taddle Creek Road, University of Toronto, M5S 1A8, Toronto, Canada.
Brain Research. Molecular Brain Research
|June 6, 2000
Abstract:
Brain dopamine D2 receptors are the main targets for antipsychotic and anti-Parkinsonian drugs. The dopamine D2 receptor has three forms, D2(Short), D2(Long) and D2(Longer). D2(Longer) is a newly found splice variant which contains two additional amino acids (valine and glutamine) in the third cytoplasmic loop of the receptor. To determine whether D2(Longer) was functional, the cDNA was transfected into CHO cells. D2(Longer) revealed a high-affinity state for dopamine ( approximately 1.5 nM), and mediated dopamine-inhibited adenylyl cyclase.