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18-hydroxylated steroids in human hypertension - clinical study
Endocrinologia Experimentalis
|March 1, 1976
Summary
Two new urinary steroids, compound X and compound Y, were detected in hypertensive patients. Their presence correlated with hypokalemia and altered urinary sodium-potassium ratios, suggesting a role in hypertension.
Area of Science:
- Endocrinology
- Nephrology
- Clinical Chemistry
Background:
- Previously reported detection of two unknown urinary steroids, X and Y.
- Compound X tentatively identified as a dihydro-18-hydroxy-DOC derivative with polar groups.
Purpose of the Study:
- Present clinical observations of 25 hypertensive patients.
- Investigate the prevalence of compounds X and Y in hypertension.
- Explore correlations with electrolyte imbalances.
Main Methods:
- Clinical observation of 25 hypertensive patients.
- Detection and analysis of urinary steroids X and Y.
- Assessment of hypokalemia and urinary Na+/K+ ratio.
Main Results:
- Compound X detected alone in 4 cases.
- Compound Y detected alone in 4 cases.
- Both compounds X and Y detected in 5 cases.
- Hypokalemia and/or decreased urinary Na+/K+ ratio observed in other cases.
Conclusions:
- Compounds X and Y are present in a subset of hypertensive patients.
- The presence of these steroids may be associated with electrolyte disturbances in hypertension.
- Further research is warranted to elucidate the exact role of these steroids in hypertensive disease.