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Mutations induced by reactive nitrogen oxide species in the supF forward mutation assay

M N Routledge1

  • 1Department of Biological Sciences, De Montfort University, The Hawthorn Building, The Gateway, LE1 9BH, Leicester, UK. mnr1@le.ac.uk

Mutation Research
|June 6, 2000
PubMed

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Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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