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Mutagenic evaluation of deltamethrin using rodent dominant lethal assay
1Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P.O. Box 80, M.G. Marg, 226 001, Lucknow, India. yshukla@itrc.sirnetd.ernet.in
Mutation Research
|June 6, 2000
Summary
Deltamethrin, a synthetic pyrethroid insecticide, showed no impairment of mating capacity or fertility in Swiss albino mice. While some post-implantation losses occurred at higher doses, a clear dose-dependent mutagenic effect was not observed.
Area of Science:
- Toxicology
- Genetics
Background:
- Synthetic pyrethroid insecticides like deltamethrin are widely used in agriculture and public health.
- Assessing the mutagenic potential of such widely used chemicals is crucial for environmental and human safety.
Purpose of the Study:
- To evaluate the mutagenic potential of deltamethrin using the dominant lethal test in Swiss albino mice.
- To determine if deltamethrin exposure affects mating capacity, fertility, and causes genetic mutations.
Main Methods:
- Swiss albino mice were orally administered three different doses of deltamethrin (0.36, 0.72, 1.08 mg/kg).
- Treated male mice were mated with untreated females weekly for six weeks.
- Female reproductive organs were examined for pre- and post-implantation losses, and mutagenic index was assessed.
Main Results:
- Deltamethrin did not impair the mating capacity or fertility of the mice.
- No significant pre-implantation losses were observed.
- Post-implantation losses were noted at medium and high doses.
- A slight, inconsistent increase in dominant lethal mutation rate was observed, lacking a clear dose-response relationship.
Conclusions:
- Deltamethrin exposure did not induce significant mutagenic effects or impair fertility in Swiss albino mice under the tested conditions.
- The observed post-implantation losses suggest potential, though not definitively dose-dependent, genotoxic effects at higher concentrations.