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The High Throughput Screening Infrastructure: The Right Tools for the Task.

Beggs1, Blok, Diels

  • 1The Automation Partnership (Cambridge) Ltd., Royston, Herts, United Kingdom.

Journal of Biomolecular Screening
|June 6, 2000
PubMed
Summary
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High-throughput screening (HTS) accelerates pharmaceutical lead identification. Effective HTS infrastructure, combining various hardware, is crucial for efficiently screening compound collections against targets.

Area of Science:

  • Drug Discovery
  • Pharmacology
  • Automation Engineering

Background:

  • High-throughput screening (HTS) is vital for pharmaceutical lead identification.
  • Recent advancements have significantly increased HTS throughput capabilities.
  • Effective HTS relies on integrated infrastructure, not just individual hardware.

Purpose of the Study:

  • To describe the experience with dedicated automation systems in HTS.
  • To highlight the importance of combining different hardware for optimal HTS performance.
  • To illustrate the development of effective HTS infrastructure tailored to organizational needs.

Main Methods:

  • Utilizing modular workstations and single-arm robotic systems.
  • Implementing recent advances in multiple-arm robotic systems.

Related Experiment Videos

  • Adopting dedicated automation systems for HTS applications.

    • Main Results:

    • Pharmaceutical companies can now screen entire compound collections within weeks to months.
    • Effective HTS infrastructure enables significant increases in throughput.
    • Dedicated automation systems offer further potential for productivity gains in HTS.

    Conclusions:

    • Successful HTS requires a well-developed infrastructure that integrates diverse hardware.
    • Dedicated automation systems represent a key advancement for enhancing HTS productivity.
    • Strategic combination of automation technologies is essential for efficient pharmaceutical lead identification.